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A Battle of Nerves: The Worry & Fear of Nerve Symptoms

Your nervous system coordinates both actions and sensory information in your body. It is made up of the central nervous system, which includes your brain and spinal column, and the peripheral nervous system, your nerves.

In May of 2021, we posted about nerve-specific topics like chronic pain, nerve tingling and numbness, and the inner workings of dizziness and vertigo. Before we dive in to the mast cell and histamine connections to all of these, you'll need to know a bit more about your nerve cells.

Neurons - what are they?

Nerves are made up of nerve cells called neurons. These cells have structures that allow them to send signals to one another at a very rapid rate.

The sending of electrochemical signals is what allows you to move your muscles for all the tasks you want to do, whether that is picking up your toothbrush in the morning to brush your teeth, or finishing a triathlon event.

Besides signalling movement, nerves also signal sensory information such as vision, smell, taste, temperature, touch, pressure, and proprioception (the ability to perceive your position in space).

What's the connection with histamine and mast cells here?

What are some of the signs and symptoms that your nerves are being impacted by histamine or mast cell mediators? Take a look at this list.

  • Pain

  • Chilling

  • Burning

  • Tingling

  • Numbness

  • Tics

  • Itch

  • Dizziness/vertigo

  • Sensory issues (that’s a topic for another blog – stay tuned)

Most of these symptoms can happen peripherally (arms and legs), but some of them such as pain or burning can happen anywhere, including in your GI tract or pelvis/bladder.

These symptoms happen because your mast cells and neurons are in close proximity to one another. This proximity allows mast cells and neurons to cross talk. The chemical mediators from the degranulation of mast cells can contribute to inflammation and physical injury of neurons (1). Curious to know what the degranulation of mast cells looks like? Check this video out.


Nerve Symptoms: possibly histamine or mast cell mediated?

There are a variety of interactions between neurons and mast cells that impact health conditions (2).

We've been posting about the link between mast cells, histamines and nerve cells for a very specific reason: we have a talk coming up on this very subject, and you can join us from anywhere in the world.

Got Pain? is happening on March 18th, 7pm Alberta time. Join us live in person in Calgary, or from the comfort of your home.

Tickets are set on a sliding scale so everyone can join in on the conversation. Link to the replay will be available for one week after the fact.

We give a bit more info on what to expect at this upcoming talk. Join us!


Want to learn more about histamine issues, and how it can play in to your symptoms you experience on a daily basis? Join our online community by clicking here. Loads of printable resources, a Master Class on the Histamine Connection. It's free to join!

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