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My Brain Isn’t Working! What’s underlying Brain Fog?


Are you absentminded or forgetful?


Do you have the ability to concentrate or stay focused the way you want to?


Are you unable to multitask?


Brain fog is common in conditions such as chronic fatigue syndrome, celiac disease, fibromyalgia, autism (ASD), mastocytosis, and postural tachycardia syndrome (POTS). (1)


Where does brain fog originate?


Brain fog can be due to inflammation in the brain. That inflammation can be the result of inflammatory chemical mediators, including histamine, from mast cells.


Mast cells view toxins, infections and certain foods as something that is dangerous to your body, and it will react to exposure to anything it views as dangerous. When mast cells are activated it stimulates the production of chemical mediators such as cytokines that can access the brain (cross the Blood Brain Barrier) and trigger the brain’s immune cells to release more chemical mediators. Many of these mediators are inflammatory.


The inflammatory mediators impact brains cells in a variety of ways and can impact the function of neurotransmitters, and neuropeptides, as well as lead to significant changes in brain activity, function (2), and plasticity (3).


Is it any wonder you have brain fog?



Getting to the root of inflammation is an important step to take when you have brain fog. Ask yourself, “where is the inflammation coming from?”


Do you have any of the symptoms of brain fog?



It’s time to think about whether histamine or mast cell activation are a contributing factor. Start by downloading our Histamine Symptoms to see if you have other symptoms that could be caused by histamine.

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